TriNetX has appointed August Calhoun as its new Chief Executive Officer, marking a significant leadership change for the global healthcare data and analytics company. The appointment is effective immediately and comes as TriNetX continues to expand its real-world data network and support clinical research across the healthcare and life sciences industries.
Calhoun brings more than 25 years of experience in healthcare technology and business leadership. His appointment reflects the company’s focus on strengthening its global operations and helping customers make better use of real-world health data to accelerate medical research and improve patient care.
Veteran healthcare executive joins TriNetX
Before joining TriNetX, August Calhoun held senior executive positions at several leading healthcare technology companies. His previous roles include leadership positions at RLDatix, Optum Insight, Change Healthcare and Siemens. Throughout his career, he has led business growth, customer operations, strategic planning and technology initiatives that support healthcare organisations around the world.
As Chief Executive Officer, Calhoun will oversee TriNetX’s global business strategy and day-to-day operations. He will also lead the company’s efforts to expand its data network, strengthen customer partnerships and advance the use of real-world evidence in clinical research.
Commenting on his appointment, Calhoun said he is excited to join TriNetX at a time when demand for trusted healthcare data continues to grow. He said the company’s global network and advanced analytics platform place it in a strong position to help healthcare providers, researchers and life sciences companies answer complex research questions and improve health outcomes.
Board highlights confidence in new leadership
Jeff Margolis, Chairman of the TriNetX Board of Directors, welcomed Calhoun to the company and expressed confidence in his leadership. He said Calhoun’s deep experience in healthcare technology, combined with his ability to scale businesses and build strong customer relationships, makes him well suited to guide TriNetX through its next stage of growth.
Margolis added that the Board looks forward to working closely with Calhoun as the company continues investing in innovation and expanding its global presence.
Joe Bress, Partner and Global Co-Head of Healthcare at Carlyle, also welcomed the appointment. He recognised the company’s recent progress, including its strategic collaboration and investment from Regeneron, the acquisition of Zetta Genomics’ assets and the continued expansion of TriNetX’s global health data network.
Building on recent momentum
TriNetX has continued to strengthen its position in the healthcare research sector by expanding its platform and collaborating with healthcare organisations worldwide. The company provides secure access to high-quality, real-world health data that supports clinical trial planning, observational research and evidence generation.
Its federated platform enables healthcare organisations to analyse data while allowing institutions to maintain control of their own information. This approach helps researchers identify suitable patient populations, improve clinical trial design and generate evidence for new treatments without moving sensitive patient data from participating organisations.
Today, TriNetX’s global network includes data representing more than 309 million patient lives across more than 20 countries and over 14,200 clinical sites, making it one of the world’s leading federated health research networks.
Supporting the future of healthcare research
The demand for real-world evidence continues to grow as pharmaceutical companies, healthcare providers and researchers seek faster and more reliable ways to develop new therapies and improve patient care. TriNetX has positioned itself as an important technology partner by connecting healthcare organisations through a secure and scalable research platform.
With August Calhoun now leading the company, TriNetX aims to build on its existing strengths while expanding its global reach and delivering new capabilities for customers. His extensive experience in healthcare technology and data-driven innovation is expected to support the company’s long-term strategy of advancing clinical research through trusted real-world data.
As healthcare organisations increasingly rely on data to improve decision-making and accelerate medical innovation, TriNetX’s leadership transition marks an important step in the company’s continued growth and commitment to supporting researchers, clinicians and life sciences organisations around the world.

